99久久人妻精品无码二区-1男1女影院内视频泄露-被黑人猛烈30分钟视频-少妇大叫太大太粗太爽了A片-窝窝午夜理论片影院-欧美日韩中文国产一区发布-午夜免费视频-国产亚洲精品精品精品-国产孰妇精品AV片国产m3u8-日韩一区二区A片免费观看-午夜AV亚洲一码二中文字幕青青-色婷婷AV99XX-国产凸凹视频熟女A片,三级片,色戒汤唯梁朝伟性视频,美女乱子伦高潮在线观看完整片,国产囗交,欧美黑人男女高甜视频,亚洲AV成人无码,亚州免费A片无码区A片,亚洲男人天堂一区二区三区,日本一本二本和三本的视频,里番本子库绅士全彩无码,国产亚洲精久久久久久无码蜜臀,级毛片内射视频,国产精品爽爽久久久久久蜜臀,爱做久久久久久,神马午夜久久,国产又爽 又黄 A片,国产视频在线观看免费,粉嫩自拍偷拍亚洲,威尼斯亚洲无码原创,国产亚洲精品久久久999无毒,欧美人妻少妇精品,啊好深好痛肉污文,啊好大好厉害好爽真骚,午夜影中文字幕,亚洲视频一区,国产精品一区福利,翁公老旺的粗大挺进晓莹,两性午夜色视频免费网站,亚洲自拍偷拍另类综合图区,亚洲高清无码在线观看免费

PirH2 has ubiquitin-protein ligase activity. It binds to p53 and promotes the ubiquitin-mediated proteosomal degradation of p53. This gene is oncogenic because loss of p53 function contributes directly to malignant tumor development. Transcription of this gene is regulated by p53 (referenced from entrez gene).[SUBUNIT] Monomer and homodimer. [SUBCELLULAR LOCATION] Nucleus. Nucleus speckle. Cytoplasm.

Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division.

GATAD2A (GATA Zinc Finger Domain Containing 2A) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein binding, bridging. An important paralog of this gene is GATAD2B.

Cytokeratin 12 is a member of the intermediate filament family of proteins and is a heterotetramer of two type I and two type II keratins. Keratin 3 is specifically expressed in the corneal epithelium with family member KRT12. Cytokeratin 12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Defects in KRT3 and KRT12 are a cause of Meesmann corneal dystrophy (MCD), an autosomal dominant disease that causes fragility of the anterior corneal epithelium.